Research

A key component of our vision is to produce new knowledge on health service strengthening through ground-breaking research. We also aim to develop future health leadership through building the research capacity of our partners in Sierra Leone. Working collaboratively with partners, key Sierra Leonean institutions, international organisations, and individuals we have been involved in the following publications:

  • Arkell, P. Youkee, D., Brown, C. S., Kamara, A., Kamara, T. B., Johnson, O., Lado, M., George, V., Koroma, F., King, M. B., Parker, B. E. and Baker, P., Quantifying the risk of nosocomial infection within Ebola Holding Units: a retrospective cohort study of negative patients discharged from five Ebola Holding Units in Western Area, Sierra Leone. Trop Med Int Health. Accepted Author Manuscript. doi:10.1111/tmi.12802
  • Brown, Colin, Paul Arkell, and Sakib Rokadiya. 2015. “Ebola virus disease: the ‘Black Swan’ in West Africa.” Tropical Doctor 45 (1):2-5. doi: 10.1177/0049475514564269.
  • Brown, Colin, Mohamed Elsherbiny, Oliver Johnson, Amardeep Kamboz, Marta Lado, Andrew Leather, Natalie Mounter, Suzanne Thomas, Dan Youkee, Naomi Walker, Waheed Awonuga, TB Kamara, Cecilia Kamara, Quannan Kessete and Ramatu Ngauja, (2016). Book Chapter: Ebola and Health Partnerships, Action in a Time of Crisis, Ebola, Dr. Crtomir Podlipnik (Ed.), InTech, DOI: 10.5772/63440. Available from: http://www.intechopen.com/books/ebola/ebola-and-health-partnerships-action-in-a-time-of-crisis
  • Bundu, I., Patel A, Mansaray A, Kamara TB, Hunt LM. Surgery in the time of Ebola: how events impacted on a single surgical institution in Sierra Leone. J R Army Med Corps. 2016 Jan 19. Available from: http://jramc.bmj.com/cgi/content/long/jramc-2015-000582v1
  • Coyle, Rachel M., and Hooi-Ling Harrison. 2015. “Emergency care capacity in Freetown, Sierra Leone: a service evaluation.” BMC emergency medicine 15:2-2. doi: 10.1186/s12873-015-0027-4.
  • Dare, AJ., Lee KC, Bleicher J, Elobu AE, Kamara TB, Liko O, et al. Prioritizing Surgical Care on National Health Agendas: A Qualitative Case Study of Papua New Guinea, Uganda, and Sierra Leone. 2016;1–25.
  • Fitzgerald F, Naveed A, Wing K, Gbessay M, Ross JCG, Checchi F, et al. Ebola virus disease in children, Sierra Leone, 2014–2015. Emerg Infect Dis. 2016 Oct. http://wwwnc.cdc.gov/eid/article/22/10/16-0579_article
  • Howlett, Patrick, Colin Brown, Trina Helderman, Tim Brooks, Durodamil Lisk, Gibrilla Deen, Marylou Solbrig, and Marta Lado. 2016. “Ebola Virus Disease Complicated by Late-Onset Encephalitis and Polyarthritis, Sierra Leone.” Emerging Infectious Diseases 22 (1):150-152. doi: 10.3201/eid2201.151212.
  • Johnson, O., Youkee, D., Brown, C. S., Lado, M., Wurie, A., Bash-Taqi, D., Hall, A.,Hanciles, E., Kamara, I., Kamara, C., Kamboz, A., Seedat, A., Thomas, S.,Kamara, T. B., Leather, A. J., & Kargbo, B. (2016). Ebola Holding Units at government hospitals in Sierra Leone: evidence for a flexible and effective model for safe isolation, early treatment initiation, hospital safety and health system functioning. BMJ Global Health, 1(1), e000030. Accessed June 22, 2016. doi: 10.1136/bmjgh-2016-000030.
  • Lado, Marta, Naomi F. Walker, Peter Baker, Shamil Haroon, Colin S. Brown, Daniel Youkee, Neil Studd, Quaanan Kessete, Rishma Maini, Tom Boyles, Eva Hanciles, Alie Wurie, Thaim B. Kamara, Oliver Johnson, and Andrew J. M. Leather. 2015. “Clinical features of patients isolated for suspected Ebola virus disease at Connaught Hospital, Freetown, Sierra Leone: a retrospective cohort study.” Lancet Infectious Diseases 15 (9):1024-1033. doi: 10.1016/s1473-3099(15)00137-1.
  • Lado, Marta, and Patrick Howlett. 2016. “Ebola virus disease in children: towards a better clinical picture and improved management.” The Lancet Global Health 4 (7):e436-e437. doi: 10.1016/S2214-109X(16)30111-5 .
  • Lowsby, R., Kamara C., Kamara M., Nyhus H., Williams N., Bradfield M., et al. An assessment of nurse-led triage at Connaught Hospital, Sierra Leone in the immediate post-Ebola period. African J Emerg Med. 2016.
  • Walker, N. F., C. S. Brown, D. Youkee, P. Baker, N. Williams, A. Kalawa, K. Russell, A. F. Samba, N. Bentley, F. Koroma, M. B. King, B. E. Parker, M. Thompson, T. Boyles, B. Healey, B. Kargbo, D. Bash-Taqi, A. J. Simpson, A. Kamara, T. B. Kamara, M. Lado, O. Johnson, and T. Brooks. 2015a. “Evaluation of a point-of-care blood test for identification of Ebola virus disease at Ebola holding units, Western Area, Sierra Leone, January to February 2015.” Eurosurveillance 20 (12). doi: http://dx.doi.org/10.2807/1560-7917.ES2015.20.12.21073
  • Youkee, Daniel, Colin S. Brown, Paul Lilburn, Nandini Shetty, Tim Brooks, Andrew Simpson, Neil Bentley, Marta Lado, Thaim B. Kamara, Naomi F. Walker, and Oliver Johnson. 2015. “Assessment of Environmental Contamination and Environmental Decontamination Practices within an Ebola Holding Unit, Freetown, Sierra Leone.” Plos One 10 (12). doi: 10.1371/journal.pone.0145167.
  • Youkee, D., Williams N, Laggah M, Howlett P, Lado M, Brady L, et al. The impact of the 2014–15 Ebola virus disease epidemic on emergency care attendance and capacity at a tertiary referral hospital in Freetown, Sierra Leone: a retrospective observational study. Lancet. 2016 Feb; 387:S109. Available from: http://www.sciencedirect.com/science/article/pii/S0140673616004967

Research Highlight: Building research capacity in clinical management of Infectious Diseases at two main adult Government Hospitals

The Ebola Virus Disease (EVD) epidemic in West Africa is one of the most significant humanitarian crises of our time. We now know that a strong and resilient health system is critical for rapid response, as well as proper management of both the outbreak and the remaining health needs of the population, which do not cease in the presence of an epidemic. Capacity to undertake research activity, both within key government institutions as well as by individual health care workers (HCWs), is an integral part of a resilient health system.

Within Freetown, both Connaught and 34 Military Hospitals are large tertiary facilities that have proven capacity for clinical management of EVD, and have also served as important sites for some EVD research activity. Research capacity will be strengthened at these institutions through the King’s Sierra Leone Partnership (KSLP). This partnership was formed in 2011 by King’s Heath Partners in London and key Sierra Leone partners, including the College of Medicine & Allied Health Sciences (COMAHS), Connaught Government Hospital and the Ministry of Health & Sanitation, with the aim of strengthening Sierra Leone’s health system by improving training, clinical services, policy and research.

Aims and Objectives

To build individual, institutional (Connaught and 34 Military hospitals) and national clinical research capacity in Infectious Disease response,  with a focus on three work streams:

  • Human Resources
  • Research Infrastructure
  • Enabling Environment

Human Resources

This stream will aim to design and deliver education and training activities, including mentoring to support senior colleagues at Connaught and 34 Military in Freetown, undergraduate students at COMAHS and health professionals from other government institutions in Freetown and across the regions. The initial focus will be on senior medical staff, early career academic clinicians, internship doctors, nursing and laboratory staff, and final year COMAHS medical students. Training will be delivered through a portfolio of methods:

  • Delivery of a research methodology course to Medical students
  • Mentoring Senior medical colleagues to develop research proposals
  • Delivery of a series of research seminars to all staff working in the ID unit.

Research Infrastructure

  • Creating an electronic patient record systems and linking it to central database
  • Developing and testing protocols for processing laboratory samples;
  • Developing clinical protocols for specific diseases
  • Creating a system for patient screening as per WHO IDSR protocols
  • Development of standardised treatment guidelines

Enabling Environment

  • Development of guidelines for rapid implementation of research studies
  • Outline systems for fast-tracked study approval

KSLP Presentation at the EDCTP-TDR- CIHR-EVD Joint Workshop in Accra, Ghana, 10 -11 Feb, 2016